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Journal of Dental Research
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Kinin Generation in the Gingival Inflammatory Response to Topically Applied Bacterial Lipopolysaccharides

E.H. Montgomery

Department of Pharmacology

R.R. White

Department of Microbiology, University of Texas Health Science Center at Houston, Dental Branch, Houston, Texas 77225

A water-soluble lipopolysaccharide from Salmonella enteritidis and a phenol-soluble lipopolysaccharide from Leptotrichia buccalis were applied topically to the healthy marginal gingivae of beagle dogs. Saline was applied to contralateral areas as an internal control. Increases in vascular permeability were monitored by measurement of gingival fluid, and the collected gingival fluid samples were assayed for kininogenase and kinin activities. Both lipopolysaccharides induced an inflammatory response, as indicated by increased gingival fluid flow. Kininogenase-kinin activities paralleled the increases in gingival fluid flow, with the highest values being associated with peak increases in gingival fluid. The results indicate that both lipopolysaccharides, although different in lipid solubility, penetrate healthy sulcular epithelium and initiate an inflammatory response which is mediated in part by the kallikrein-kinin system. Interrelationships between this system and other inflammatory mediators suggest that kinin generation not only plays a role in the early phases of acute gingival inflammation, but may also contribute to the activation of other mediators appearing later in the response and in chronic inflammatory lesions.

Journal of Dental Research, Vol. 65, No. 2, 113-117 (1986)
DOI: 10.1177/00220345860650020301
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S. Hamada, T. Koga, T. Nishihara, T. Fujiwara, and N. Okahashi
Characterization and Immunobiologic Activities of Lipopolysaccharides From Periodontal Bacteria
Advances in Dental Research, November 1, 1988; 2(2): 284 - 291.
[Abstract] [PDF]