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Journal of Dental Research
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Metronidazole Concentrations in Human Plasma, Saliva, and Gingival Crevice Fluid after a Single Dose

M.A.C. Van Oosten

Department of Preventive and Community Dentistry, University of Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands

F.J.W. Notten

Department of Preventive and Community Dentistry, University of Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands

F.H.M. Mikx

Department of Preventive and Community Dentistry, University of Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands

Metronidazole concentrations were estimated in four human volunteers after a single dose of 750 mg taken orally. Samples of blood, saliva, and gingival crevice fluid were collected before intake and during the following 24 hours.

The concentrations of metronidazole in plasma and saliva were measured by high-performance liquid chromatography (HPLC). The concentrations in gingival fluid were estimated by a capillary agar-diffusion assay. The results of the metronidazole measurements as obtained by both methods were significantly correlated. The peak concentrations of metronidazole in plasma and saliva were in the same range, 8.7-13.8 µ g/mL, and similar concentrations were found in the gingival fluid samples.

It is concluded that metronidazole taken orally has similar pharmacokinetics in both saliva and plasma, and that a single oral dose of 750 mg metronidazole leads to a concentration of the drug in the gingival crevice fluid that exceeds the minimal inhibitory concentration for most anaerobic oral micro-organisms.

Journal of Dental Research, Vol. 65, No. 12, 1420-1423 (1986)
DOI: 10.1177/00220345860650120801
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