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Journal of Dental Research
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Immunoglobulins and Innate Antimicrobial Factors in Whole Saliva of Patients with Insulin-dependent Diabetes Mellitus

J. Tenovuo

Institute of Dentistry

O.-P. Lehtonen

Department of Medical Microbiology

J. Vkari

Department of Medicine, University of Turku, 20520 Turku 52, Finland

H. Larjava

Institute of Dentistry

P. Vilja

Department of Biomedical Sciences, University of Tampere, 33100 Tampere 10. Finland

P. Tuohimaa

Department of Biomedical Sciences, University of Tampere, 33100 Tampere 10. Finland

We analyzed the flow rate and composition of paraffin-stimulated whole saliva samples from 35 adult diabetic patients and their age- and sex-matched, non-diabetic, clinically healthy controls. All patients had insulin-dependent diabetes (IDDM) with a mean (± S.D.) duration of 14.0 ± 9.1 years. The saliva analysis included the quantitation of total protein, amylase, immunoglobulins (isotypes A, G, and M), and the non-antibody, innate antimicrobial factors (lysozyme, lactoferrin, salivary peroxidase, myeloperoxidase, thiocyanate, and hypothiocyanite). The whole saliva samples from diabetic patients had significantly higher amounts of IgA (p < 0.001) and IgG (p < 0.05) than did the controls. No differences between the study groups were observed in flow rate, protein content, amylase activity, or IgM. The levels of innate defense factors were similar in both study groups except for salivary peroxidase, which was higher (p < 0.02) among diabetics than among controls. Our results indicate that the antimicrobial defense capacity of whole saliva is not impaired in diabetic patients.

Journal of Dental Research, Vol. 65, No. 1, 62-66 (1986)
DOI: 10.1177/00220345860650011101
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J.D. Rudney
Does Variability in Salivary Protein Concentrations Influence Oral Microbial Ecology and Oral Health?
Critical Reviews in Oral Biology & Medicine, January 1, 1995; 6(4): 343 - 367.
[Abstract] [Full Text] [PDF]

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J. Tenovuo, E. Grahn, O.-P. Lehtonen, T. Hyyppa, L. Karhuvaara, and P. Vilja
Antimicrobial Factors in Saliva: Ontogeny and Relation to Oral Health
Journal of Dental Research, February 1, 1987; 66(2): 475 - 479.
[Abstract] [PDF]