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Journal of Dental Research
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Pharmacological Studies on the Anti-inflammatory Action of Phenolic Compounds

Y. Azuma

Department of Dental Pharmacology, School of Dentistry, Asahi University, Hozumi, Hozumi-Cho, Motosu-Gun, Gifu 501-02, Japan

N. Ozasa

Department of Dental Pharmacology, School of Dentistry, Asahi University, Hozumi, Hozumi-Cho, Motosu-Gun, Gifu 501-02, Japan

Y. Ueda

Department of Dental Pharmacology, School of Dentistry, Asahi University, Hozumi, Hozumi-Cho, Motosu-Gun, Gifu 501-02, Japan

N. Takagi

Department of Dental Pharmacology, School of Dentistry, Asahi University, Hozumi, Hozumi-Cho, Motosu-Gun, Gifu 501-02, Japan

The mechanism of the anti-inflammatory action of phenolic compounds was examined using neutrophil chemotaxis. Chemotactic activity of guinea pig peritoneal neutrophils to N-formylmethionyl-leucylphenylalanine (FMLP) was suppressed in a concentration-dependent manner. The order of drug potency in inhibiting the neutrophil chemotaxis was eugenol » thymol > guaiacol » phenol. The concentrations of phenolic compounds used in these experiments did not induce lactate dehydrogenase (LDH) release and did not affect neutrophil viability. There was a consistent positive relation between the ID50 of superoxide anion generation in neutrophils and the inhibitory dose for neutrophil chemotaxis by phenolic compounds. A free phenolic hydroxyl group is essential for scavenging oxygen free-radicals and is also essential for inhibiting leukocyte chemotaxis, as was demonstrated in these experiments. These findings suggest that inhibition of leukocyte chemotaxis may be involved in the anti-inflammatory action of phenolic compounds, and that one of the anti-inflammatory actions of phenolic compounds is the prevention of the production of oxygen free-radicals by leukocytes.

Journal of Dental Research, Vol. 65, No. 1, 53-56 (1986)
DOI: 10.1177/00220345860650010901
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