This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Abe, K. Articles by Yokota, Y. Search for Related Content PubMed PubMed Citation Articles by Abe, K. Articles by Yokota, Y. Social Bookmarking                         What's this?

Effects of the Selective β2-Adrenergic Agonists, Procaterole and Terbutaline, on Protein Secretion by Rat Submandibular Glands

Department of Oral Biochemistry

H. Inoue

The First Department of Conservative Dentistry, Fukuoka Dental College, 700, Ta, Sawara-ku, Fukuokashi 814-01

Y. Yokota

Department of Oral Biochemistry, Gifu College of Dentistry, Gifu 501-02, Japan

We examined the secretory effects of two β₂-adrenergic agonists, procaterole and terbutaline, on the submandibular glands of anesthetized rats. After stimulation with these agents with and without a range of antagonists (non-specific - and β-adrenergic blockers), submandibular saliva was collected. The flow rate, protein concentration, the electrophoretic patterns, and amino acid composition of saliva were examined. These parameters were compared with their counterparts in saliva stimulated with isoproterenol (IPR), with and without antagonists. Assessed by these criteria, secreted proteins were classified as the - or β-type. In addition, IPR-stimulated proteins were compared in submandibular saliva of rats chronically treated with IPR or procaterole.

Both β₂-agonists were potent secretagogues for the submandibular glands of rats. All β-antagonists completely abolished the secretory effects elicited by both β₂-agonists, with the exceptions of carteolol and propranolol. However, no blocking agent abolished the secretory effects of IPR (60 mg/kg). The types of proteins in all submandibular saliva samples elicited by both β₂-agonists with and without antagonists were the β-type. Enlargement of the submandibular glands was not observed in rats subjected to chronic administration of procaterole, nor were abnormal and additional proteins observed, as confirmed by electrophoresis and by the amino acid analyses.

Journal of Dental Research, Vol. 64, No. 6, 886-890 (1985)
DOI: 10.1177/00220345850640060501


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				K. Ishibashi, K. Okamura, and J. Yamazaki Involvement of apical P2Y2 receptor-regulated CFTR activity in muscarinic stimulation of Cl- reabsorption in rat submandibular gland Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1729 - R1736. [Abstract] [Full Text] [PDF]

				A. Okina, K. Abe, M. Tashiro, and K. Ishibashi The Effects of p-Octopamine on Salivary Flow Rates and Protein Secretion by Rat Submandibular Glands Journal of Dental Research, June 1, 1993; 72(6): 993 - 1000. [Abstract] [PDF]

				A. Okina, S. Hidaka, M. Tashiro, and K. Abe The Effects of Tyramine on Salivary Flow Rate and Protein Secretion by Rat Submandibular Glands Journal of Dental Research, May 1, 1993; 72(5): 897 - 906. [Abstract] [PDF]

				G. S. Bedi The Effect of Adrenergic Agonists and Antagonists on the Expression of Proteins in Rat Submandibular and Parotid Glands Critical Reviews in Oral Biology & Medicine, January 1, 1993; 4(3): 565 - 571. [Abstract] [Full Text] [PDF]

				D.A. Johnson and J.E. Cortez Chronic Treatment with Beta Adrenergic Agonists and Antagonists Alters the Composition of Proteins in Rat Parotid Saliva Journal of Dental Research, August 1, 1988; 67(8): 1103 - 1108. [Abstract] [PDF]