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Journal of Dental Research
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Contribution of Extracellular and Intracellular Calcium to the Enhanced Effect of an a-Adrenergic Agonist on Amylase Release from Dispersed Rat Parotid Cells

H. Takemura

Department of Pharmacology, Sapporo Medical College, S.1, W.17, Sapporo 060, Japan

H. Ohshika

Department of Pharmacology, Sapporo Medical College, S.1, W.17, Sapporo 060, Japan

The role of calcium in the potentiation of amylase release by the {alpha}-adrenergic agonist methoxamine (MTX) was examined using dispersed rat parotid acinar cells. The stimulatory effect of MTX (10 µM) on the β-adrenergic agonist isoproterenol (ISP, 1 µM)-induced amylase release was blocked by the {alpha}-adrenergic antagonist phentolamine (10 µM). In Ca-free (1 mM EGTA) medium, the increment of amylase release by MTX in normal medium was decreased by about 70%, but MTX still potentiated ISP-induced amylase release, MTX did not affect the cyclic AMP accumulation activated by ISP in either normal or Ca-free medium. MTX enhanced the ISP-stimulated uptake and efflux of 45Ca2+. These results suggest that both extracellular Ca2+ and intracellular stored Ca2+ may play an important role in the potentiation of amylase release from rat parotid acinar cells.

Journal of Dental Research, Vol. 64, No. 6, 881-885 (1985)
DOI: 10.1177/00220345850640060401
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