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Journal of Dental Research
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*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*CALCIUM CHLORIDE
*CALCIUM COMPOUNDS
*CALCIUM, ELEMENTAL
*DISODIUM PHOSPHATE
*PHOSPHORUS
*SODIUM DIHYDROGEN PHOSPHATE
*TRISODIUM PHOSPHATE
*UREA
Medline Plus Health Information
*Minerals
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What's this?

Immediate and Delayed Effects of an Enzyme-dependent Mineralizing Mouthrinse on Dental Plaque

R.G. Schamschula

Institute of Dental Research, 2 Chalmers Street, Surry Hills, N.S.W., 2010, Australia

E.I.F. Pearce

Dental Unit, Medical Research Council of NZ, P.O. Box 27007, Wellington, New Zealand

P.S.H. Un

Institute of Dental Research, 2 Chalmers Street, Surry Hills, N.S.W., 2010, Australia

M.H. Cooper

Health Commission of New South Wales, P.O. Box 790, Dubbo, N.S. W., 2830, Australia

Twenty-two children aged 13 to 14 years rinsed for 3 x 1 min periods with a supersaturated cadcium phosphate solution containing urea and monofluorophosphate. Plaque sampled one min after the last rinse showed a marked increase in water-extractable F and a smaller increase in Ca but no increase in water-extractable P. Water-insoluble forms of all three ions were elevated, however. The mean pdaque pH was 8.28. Plaque sampled 24 hr after the last rinse showed significant increases in water-insoluble F and Ca only, and no increase in pH. The prompt pH rise and disappearance of watersoluble P suggest that, on exposure to the mineralizing solution, urea and monofluorophosphate are rapidly hydrolyzed by plaque enzymes to provide catabolites which cause the immediate precipitation of fluoridated calcium phosphate.

Journal of Dental Research, Vol. 64, No. 3, 454-456 (1985)
DOI: 10.1177/00220345850640031301
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E.I.F. Pearce, J.ST.J. Wakefield, and C.H. Sissons
Therapeutic Mineral Enrichment of Dental Plaque Visualized by Transmission Electron Microscopy
Journal of Dental Research, February 1, 1991; 70(2): 90 - 94.
[Abstract] [PDF]