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Journal of Dental Research
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Serotype c Streptococcus mutans Mutatable to Lactate Dehydrogenase Deficiency

S. Abhyankar

Faculty of Dentistry, University of Toronto, Toronto, ON, Canada M5G IG6

H.J. Sandham

Faculty of Dentistry, University of Toronto, Toronto, ON, Canada M5G IG6

K.H. Chan

Faculty of Dentistry, University of Toronto, Toronto, ON, Canada M5G IG6

Three lactate-dehydrogenase-deficient mutants of serotype c S. mutans were made by using, as parents, two serotype c strains that produced unusually large amounts of ethanol, acetic acid, and acetoin, and very little lactic acid, when grown in broth containing a limiting amount of glucose. The mutants, obtained with N-methyl-N'nitro-N-nitrosoguanidine, were stable during 12 weeks of daily subculture in broth. Crude cell-free extracts of the mutants had less than 1% of the LDH-specific activity of their parent strains. The serotype c mutants resembled serotype g mutants in having molar growth yields at least as high as those of their parents. However, in contrast to the g mutants, the c mutants produced cell crops (cell mass per ml medium) that were as high as those of their parent strains.

Journal of Dental Research, Vol. 64, No. 11, 1267-1271 (1985)
DOI: 10.1177/00220345850640110201
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