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Journal of Dental Research
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Ultrastructural Changes in the Cementoblasts of Rat Molars after Injection of Vincristine

S. Takuma

Department of Oral Pathology, Tokyo Dental College, Masago 1-2-2, Chiba City 260, Japan

T. Sawada

Department of Oral Pathology, Tokyo Dental College, Masago 1-2-2, Chiba City 260, Japan

S. Yama

Department of Oral Pathology, Tokyo Dental College, Masago 1-2-2, Chiba City 260, Japan

T. Yanagisawa

Department of Oral Pathology, Tokyo Dental College, Masago 1-2-2, Chiba City 260, Japan

Cytological changes in the cementoblasts of rats treated with vincristine were investigated. Accumulation of secretion granules indicated a disturbed secretory mechanism in the cells. Conspicuous dilation of the endoplasmic reticulum suggested disturbance in the transport of substances from the rough endoplasmic reticulum to the Golgi elements. These disturbances were interpreted to be a result of disruption of microtubules.

Journal of Dental Research, Vol. 63, No. 9, 1108-1115 (1984)
DOI: 10.1177/00220345840630090201
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