Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Hume, W.R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hume, W.R.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

An Analysis of the Release and the Diffusion Through Dentin of Eugenol from Zinc Oxide-Eugenol Mixtures

W.R. Hume

The University of Adelaide, School of Dentistry, Adelaide, South Australia 5000, Australia

Tritium-labeled eugenol was released from mixtures of zinc oxide eugenol (ZOE) into aqueous solution at rates which declined exponentially with time, and which were directly proportional to the liquid-powder ratio. The release pattern was consistent with a model of progressive hydrolysis of zinc eugenolate in a limited-thickness ZOE surface layer. Intervening dentin had a profound effect on this pattern of release. In human teeth in vitro containing ZOE as a base or temporary filling, peak eugenol release at the pulpal surface of dentin was of the order of a thousand-fold less than that at the salivary surface. In such teeth, eugenol reached concentrations in excess of 10-2 M in dentin just beneath ZOE, and 10-4 M or less adjacent to the pulp space. Both pulpal outflow and dentin concentrations of eugenol remained relatively constant for more than a week, unlike release into aqueous solution. While these data were derived from studies on human teeth in vitro, they give a strong indication of probable events in vivo, and appear to provide a basis for the explanation of the paradox of the therapeutic and toxic actions of ZOE.

Journal of Dental Research, Vol. 63, No. 6, 881-884 (1984)
DOI: 10.1177/00220345840630061301
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Journal of the American Dental AssociationHome page
M. A. Pogrel
Damage to the inferior alveolar nerve as the result of root canal therapy
J Am Dent Assoc, January 1, 2007; 138(1): 65 - 69.
[Abstract] [Full Text] [PDF]

Home page
 CROBMHome page
G. Bergenholtz
Evidence for Bacterial Causation of Adverse Pulpal Responses in Resin-Based Dental Restorations
Critical Reviews in Oral Biology & Medicine, January 1, 2000; 11(4): 467 - 480.
[Abstract] [Full Text] [PDF]

Home page
 CROBMHome page
P. Stashenko, R. Teles, and R. D'Souza
Periapical Inflammatory Responses and Their Modulation
Critical Reviews in Oral Biology & Medicine, January 1, 1998; 9(4): 498 - 521.
[Abstract] [Full Text] [PDF]

Home page
 JDRHome page
H. R. Stanley
Trashing the Dental Literature-Misleading the General Practitioners: A Point of View
Journal of Dental Research, September 1, 1996; 75(9): 1624 - 1626.
[PDF]

Home page
 CROBMHome page
W.R. Hume and T.M. Gerzina
Bioavailability of Components of Resin-Based Materials Which Are Applied To Teeth
Critical Reviews in Oral Biology & Medicine, January 1, 1996; 7(2): 172 - 179.
[Abstract] [Full Text] [PDF]

Home page
 JDRHome page
S. Kasugai, N. Hasegawa, and H. Ogura
Application of the MTT Colorimetric Assay to Measure Cytotoxic Effects of Phenolic Compounds on Established Rat Dental Pulp Cells
Journal of Dental Research, February 1, 1991; 70(2): 127 - 130.
[Abstract] [PDF]

Home page
 JDRHome page
S. Fujisawa, Y. Kadoma, and Y. Komoda
1H and 13C NMR Studies of the Interaction of Eugenol, Phenol, and Triethyleneglycol Dimethacrylate with Phospholipid Liposomes as a Model System for Odontoblast Membranes
Journal of Dental Research, November 1, 1988; 67(11): 1438 - 1441.
[Abstract] [PDF]

Home page
 JDRHome page
S. Hashimoto, K. Uchiyama, M. Maeda, K. Ishitsuka, K. Furumoto, and Y. Nakamura
In vivo and in vitro Effects of Zinc Oxide-Eugenol (ZOE) on Biosynthesis of Cyclo-oxygenase Products in Rat Dental Pulp
Journal of Dental Research, August 1, 1988; 67(8): 1092 - 1096.
[Abstract] [PDF]

Home page
 JDRHome page
W.R. Hume and G.J. Mount
In vitro Studies on the Potential for Pulpal Cytotoxicity of Glass-Ionomer Cements
Journal of Dental Research, June 1, 1988; 67(6): 915 - 918.
[Abstract] [PDF]

Home page
 JDRHome page
P.G. Fotos, C.J. Woolverton, K. Van Dyke, and R.L. Powell
Effects of Eugenol on Polymorphonuclear Cell Migration and Chemiluminescence
Journal of Dental Research, March 1, 1987; 66(3): 774 - 777.
[Abstract] [PDF]

Home page
 JDRHome page
W.R. Hume
A New Technique for Screening Chemical Toxicity to the Pulp from Dental Restorative Materials and Procedures
Journal of Dental Research, November 1, 1985; 64(11): 1322 - 1325.
[Abstract] [PDF]