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Neutrophil Receptor Modulation in the Pathogenesis of Periodontal Diseases

T.E. Van Dyke

Department of Periodontology and Oral Biology, Emory University School of Dentistry, Atlanta, Georgia 30322

The role of the neutrophil as a primary protective cell in the pathogenesis of periodontal disease has been well established. In this paper, the role of receptor modulation on the neutrophil surface is discussed as a possible mechanism for neutrophil functional abnormalities. Using localized juvenile periodontitis (LJP) as a model, the direct inhibition of neutrophils by bacterial products is discussed as a possible mechanism for local neutrophil dysfunction. In both disease processes, neutrophil receptor modulation plays a central role.

Journal of Dental Research, Vol. 63, No. 3, 452-454 (1984)
DOI: 10.1177/00220345840630031701
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