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The Anti-cariogenic Potential of Xylitol in Comparison with Sodium Fluoride in Rat Caries ExperimentsDepartments of Preventive Dentistry and Oral Microbiology, School of Dentistry, University of Utrecht, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands Previous rat caries experiments in our laboratory demonstrated an anti-cariogenic and most probably a remineralizing effect of xylitol. The purpose of the present study was to compare the caries-inhibiting property of xylitol and fluoride in drinking water. The study consisted of two experiments with Osborne-Mendel rats, superinfected with S. mutans. In the first experiment, the rats were fed ad libitum a cariogenic diet containing 20% sucrose and 5% glucose (diet SSP 20/5) and tap water containing 0%, 2%, or 4% xylitol. An additional control group was fed diet SSP 20/5 supplemented with 5% xylitol. In the second experiment, the rats were also fed diet SSP 20/5, but received tap water, demineralized water (both containing less than 0.1 ppm F-), or tap water containing 10 and 40 ppm fluoride. Some animals in the 4% xylitol drinking water group showed a mild osmotic diarrhea for the first four days and a retarded increase in body weight of limited duration. S. mutans colonized to a similar level in all groups of both experiments. Fluoride as well as xylitol in the drinking water reduced the fissure caries scores significantly. However, 10 and 40 ppm fluoride had a more pronounced inhibiting effect on the caries experience than did 4% xylitol in the drinking water or 5% xylitol in the diet.
Journal of Dental Research, Vol. 63, No. 2,
120-123 (1984) This article has been cited by other articles:
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