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Journal of Dental Research
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Screening of Sugars Inhibitory against Sucrose-dependent Synthesis and Adherence of Insoluble Glucan and Acid Production by Streptococcus mutans

S. Imai

Department of Dental Research, National Institute of Health, 2-10-35, Kamiosaki, Shinagawa-ku, Tokyo 141, Japan

K. Takeuchi

Department of Dental Research, National Institute of Health, 2-10-35, Kamiosaki, Shinagawa-ku, Tokyo 141, Japan

K. Shibata

Department of Dental Research, National Institute of Health, 2-10-35, Kamiosaki, Shinagawa-ku, Tokyo 141, Japan

S. Yoshikawa

Department of Biochemistry, Osaka Municipal Technical Research Institute, 2-1-1, Oogimachi, Kita-ku, Osaka 530, Japan

S. Kitahata

Department of Biochemistry, Osaka Municipal Technical Research Institute, 2-1-1, Oogimachi, Kita-ku, Osaka 530, Japan

S. Okada

Department of Biochemistry, Osaka Municipal Technical Research Institute, 2-1-1, Oogimachi, Kita-ku, Osaka 530, Japan

S. Araya

Department of Dental Research, National Institute of Health, 2-10-35, Kamiosaki, Shinagawa-ku, Tokyo 141, Japan

T. Nisizawa

Department of Dental Research, National Institute of Health, 2-10-35, Kamiosaki, Shinagawa-ku, Tokyo 141, Japan

Various sucrose derivatives and a sucrose analogue were enzymatically synthesized on the assumption that structural similarities of the sugars to sucrose would endow them with an ability to inhibit the cariogenicity of sucrose. The effect of these sugars on sucrose-dependent synthesis and adherence of insoluble glucan and on acid fermentation of sucrose by Streptococcus mutans was examined in vitro. Although none of them inhibited the acid fermentation, several sugars not only inhibited the synthesis and adherence of insoluble glucan, but were themselves only slightly fermented as well.

Journal of Dental Research, Vol. 63, No. 11, 1293-1297 (1984)
DOI: 10.1177/00220345840630110801
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