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Juvenile Periodontitis as a Model for Neutrophil Function: Reduced Binding of the Complement Chemotactic Fragment, C5a

State University of New York at Buffalo, Departments of Oral Biology and Endodontics, 312 Cary Hall, Buffalo, New York 14214

M.J. Levine

State University of New York at Buffalo, Departments of Oral Biology and Endodontics, 312 Cary Hall, Buffalo, New York 14214

L.A. Tabak

State University of New York at Buffalo, Departments of Oral Biology and Endodontics, 312 Cary Hall, Buffalo, New York 14214

R.J. Genco

State University of New York at Buffalo, Departments of Oral Biology and Endodontics, 312 Cary Hall, Buffalo, New York 14214

The binding of the chemotactic complement fragment, C5a, to peripheral blood neutrophils of Localized Juvenile Periodontitis (LJP) patients and normal controls was quantitated using iodinated human C5a and a rapid centrifugation assay. There was a significant reduction in the number of binding sites per cell on neutrophils from the patient group, whereas the binding affinity remained the same as control values.

Journal of Dental Research, Vol. 62, No. 8, 870-872 (1983)
DOI: 10.1177/00220345830620080301


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