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Journal of Dental Research
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*ACETYLSALICYLIC ACID
*COLCHICINE
*PREDNISOLONE
*PROCAINE
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Nuclear Magnetic Resonance Spectroscopic Studies of the Interaction of Phospholipids with Stabilizing Lysosome Agents

S. Fujisawa

School of Dentistry, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113

Y. Kadoma

Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, 2-3-10 Surugadai, Kanda, Chiyoda-ku, Tokyo 101, Japan

E. Masuhara

Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, 2-3-10 Surugadai, Kanda, Chiyoda-ku, Tokyo 101, Japan

The interaction between phospholipids and stabilizing lysosome agents such as acetylsalicylic acid (ASA), colchicine (CC), prednisolone (PD), etc., was studied using NMR spectroscopy. The peak intensity of protons arising from these compounds was reduced in liposomes containing lecithin and various agents with a molar ratio of 1:1 in D2O. The reduced percentage of protons in the agents differed due to their molecular structures: ASA was about 20%, CC about 30%, and PD about 100%.

Journal of Dental Research, Vol. 62, No. 7, 803-805 (1983)
DOI: 10.1177/00220345830620070501
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S. Fujisawa, Y. Kadoma, and Y. Komoda
1H and 13C NMR Studies of the Interaction of Eugenol, Phenol, and Triethyleneglycol Dimethacrylate with Phospholipid Liposomes as a Model System for Odontoblast Membranes
Journal of Dental Research, November 1, 1988; 67(11): 1438 - 1441.
[Abstract] [PDF]