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Journal of Dental Research
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Effect of Dichloromethylene Diphosphonate on Fluoride Balance in Healthy Men

U.R. Maheshwari

Department of Oral Medicine and Hospital Dentistry, School of Dentistry, University of California, San Francisco, California 94143

L. Leybin

Department of Oral Medicine and Hospital Dentistry, School of Dentistry, University of California, San Francisco, California 94143

J.T. McDonald

U.S. Public Health Service Hospital, San Francisco, California 94118

V.S. Schneider

U.S. Public Health Service Hospital, San Francisco, California 94118

E. Newbrun

Department of Oral Medicine and Hospital Dentistry, School of Dentistry, University of California, San Francisco, California 94143

H.C. Hodge

Department of Oral Medicine and Hospital Dentistry, School of Dentistry, University of California, San Francisco, California 94143, Department of Pharmacology, School of Medicine, UCSF, Department of Community and Environmental Medicine, California College of Medicine, University of California, Irvine, California 92717

Healthy men with a daily intake of 0.37 mg fluoride were given dichloromethylene diphosphonate (Cl 2MDP) or a placebo during a period of ambulation followed by bed rest. In both groups, serum ionic fluoride was unchanged, and fluoride balances were negative, but Cl2MDP significantly reduced loss of fluoride in the treated groups.

Journal of Dental Research, Vol. 62, No. 5, 559-561 (1983)
DOI: 10.1177/00220345830620051001
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