Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Kantor, M.L.
Right arrow Articles by Hassell, T.M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Kantor, M.L.
Right arrow Articles by Hassell, T.M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Increased Accumulation of Sulfated Glycosaminoglycans in Cultures of Human Fibroblasts from Phenytoin-induced Gingival Overgrowth

M.L. Kantor

Department of Periodontics, School of Dentistry, and Dental Research Center, University of North Carolina, Chapel Hill, North Carolina 27514

T.M. Hassell

Department of Periodontics, School of Dentistry, and Dental Research Center, University of North Carolina, Chapel Hill, North Carolina 27514

Long-term ingestion of phenytoin elicits gingival overgrowth. We investigated sulfated glycosaminoglycan (GAG) metabolism by human gingival fibroblasts from normal gingivae and from phenytoin-enlarged gingivae. Incorporation, utilization, and subsequent loss of 35SO4= was measured in pulse-chase experiments. Fibroblasts from overgrown gingivae demonstrated increased accumulation of sulfated glycosaminoglycans. The increase was due to elevated synthesis and not to decreased degradation.

Journal of Dental Research, Vol. 62, No. 3, 383-387 (1983)
DOI: 10.1177/00220345830620031601
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 CROBMHome page
T. M. Hassell and A. F. Hefti
Drug-Induced Gingival Overgrowth: Old Problem, New Problem
Critical Reviews in Oral Biology & Medicine, January 1, 1991; 2(1): 103 - 137.
[Full Text] [PDF]

Home page
 Toxicol PatholHome page
T. Waner, A. Nyska, M. Nyska, M. Pirak, M. Sela, and A. Galiano
Gingival Hyperplasia in Dogs Induced by Oxodipine, a Calcium Channel Blocking Agent
Toxicol Pathol, April 1, 1988; 16(3): 327 - 332.
[Abstract] [PDF]

Home page
 Arch DermatolHome page
L. S. Moy, E. M. L. Tan, R. Holness, and J. Uitto
Phenytoin Modulates Connective Tissue Metabolism and Cell Proliferation in Human Skin Fibroblast Cultures
Arch Dermatol, January 1, 1985; 121(1): 79 - 83.
[Abstract] [PDF]