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Biosynthesis of 17β-estradiol and Its Binding to Specific Receptors in Human Gingiva

Departments of Medicine and Dentistry, New York Medical College, Valhalla, New York 10595

G.G. Gordon

Departments of Medicine and Dentistry, New York Medical College, Valhalla, New York 10595

P.R. Munnangi

Departments of Medicine and Dentistry, New York Medical College, Valhalla, New York 10595

S.C. Rappaport

Departments of Medicine and Dentistry, New York Medical College, Valhalla, New York 10595

A.L. Southren

Departments of Medicine and Dentistry, New York Medical College, Valhalla, New York 10595

An increased biosynthesis of 17β-estradiol was found by microsomes obtained from the inflamed human gingivae when compared to those from healthy and hyperplastic tissues. In contrast, binding of estradiol to cytoplasmic receptors was increased only in hyperplastic tissue and was independent of the amount of estradiol formed.

Journal of Dental Research, Vol. 62, No. 3, 341-343 (1983)
DOI: 10.1177/00220345830620030701


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