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Journal of Dental Research
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Basic Biological Sciences

Dispersed Rat Parotid Cells: Role of Calcium and cAMP in the Regulation of Amylase Secretion

D.O. Quissell

Department of Biochemistry, Biophysics, and Genetics, and Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262

J.L. Lafferty

Department of Biochemistry, Biophysics, and Genetics, and Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262

K.A. Barzen

Department of Biochemistry, Biophysics, and Genetics, and Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262

The inter-relationship between cellular calcium and cAMP in the regulation of amylase secretion in dispersed rat parotid cells was evaluated. {alpha}-adrenergic stimulation augmented β-adrenergic receptor-mediated amylase release. Cellular calcium depletion was unable to completely block amylase secretion.

Journal of Dental Research, Vol. 62, No. 2, 131-134 (1983)
DOI: 10.1177/00220345830620020901
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H. Takemura and H. Ohshika
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