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Journal of Dental Research
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Fluoride Concentrations in Rat and Human Tooth Pulps and Their Possible Interference with Phosphatase Activities

Y. Ericsson

Karolinska Institute, School of Dentistry, Department of Cariology and Laboratory of Oral Biochemistry, S - 103 64 Stockholm, Sweden

B. Angmar-Mansson

Karolinska Institute, School of Dentistry, Department of Cariology and Laboratory of Oral Biochemistry, S - 103 64 Stockholm, Sweden

Alkaline and acid phosphatases (p-ases), fluoride (F), and calcium (Ca) were analyzed in the pulps of rat incisors and young human pre-molars. P-ase activities were about ten times higher in the rat than in the human pulps; in the latter, high p-ase activity appeared to be connected with rapid mineralization. Average total F was 3-4 ng/mg in both rat and human pulp, while Ca showed values several times higher, although greatly varying, in human than in rat pulps. Ionized F was two to three times higher in ultrafiltrates from rat and human pulps than in the blood plasma of the species; in the rat, the F content of the ultrafiltrates increased only three to four times when plasma F was experimentally elevated over 100 times. In vitro, rat pulp alk. p-ase activity was slightly inhibited only in the range above 100 mM NaF, while acid p-ase showed weak inhibition in the region from 0.15-0.25 mM and 40-60% inhibition in the range from 10-100 mM NaF. In vivo, no effect on pulp p-ases was found, even from sublethal NaF doses.

Journal of Dental Research, Vol. 62, No. 12, 1196-1200 (1983)
DOI: 10.1177/00220345830620120401
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