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Journal of Dental Research
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Modulation of in vitro Human Lymphocyte Responses by an Exopolysaccharide from Capnocytophaga ochracea

R.W. Bolton

Departments of Oral Biology and Periodontics, College of Dentistry, University of Nebraska Medical Center, Lincoln, Nebraska 68583-0740

J.K. Dyer

Departments of Oral Biology and Periodontics, College of Dentistry, University of Nebraska Medical Center, Lincoln, Nebraska 68583-0740

R.A. Reinhardt

Departments of Oral Biology and Periodontics, College of Dentistry, University of Nebraska Medical Center, Lincoln, Nebraska 68583-0740

D.K. Okano

Departments of Oral Biology and Periodontics, College of Dentistry, University of Nebraska Medical Center, Lincoln, Nebraska 68583-0740

An exopolysaccharide (EP), purified from spent culture fluid previously inoculated with Capnocytophaga ochracea strain 25, suppressed in vitro human peripheral blood lymphocyte responses to the mitogen concanavalin A. EP was suppressive when added to cultures before the mitogen, but enhanced responses when added 24 or 48 hr after the mitogen.

Journal of Dental Research, Vol. 62, No. 12, 1186-1189 (1983)
DOI: 10.1177/00220345830620120201
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