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Journal of Dental Research
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Plasma Beta-Endorphin-like Immunoreactivity, Pain and Anxiety Following Administration of Placebo in Oral Surgery Patients

K.M. Hargreaves

Neurobiology and Anesthesiology Branch, National Institute of Dental Research, NIH, Bethesda, MD 20205, Georgetown University School of Dentistry, Washington, DC 20007

R.A. Dionne

Neurobiology and Anesthesiology Branch, National Institute of Dental Research, NIH, Bethesda, MD 20205

G.P. Mueller

Department of Physiology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814

Plasma beta-endorphin was measured in patients undergoing a stressful procedure, the removal of impacted third molars. In patients reporting little pain, endorphin levels increased significantly during surgery, whereas patients reporting pain and anxiety showed little increase in endorphin levels.

Journal of Dental Research, Vol. 62, No. 11, 1170-1173 (1983)
DOI: 10.1177/00220345830620111601
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 Anesth. Analg.Home page
R. Matejec, R. Ruwoldt, R.-H. Bodeker, G. Hempelmann, and H. Teschemacher
Release of {beta}-Endorphin Immunoreactive Material Under Perioperative Conditions into Blood or Cerebrospinal Fluid: Significance for Postoperative Pain?
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[Abstract] [Full Text] [PDF]