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Journal of Dental Research
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Action of Drugs on Liposomes with Varying Charges

S. Fujisawa

School of Dentistry, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113, Japan

Y. Kadoma

Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, 2-3-10 Surugadai, Kanda, Chiyoda-ku, Tokyo 101, Japan

E. Masuhara

The effects of 12 amphipathic compounds-such as aromatic and aliphatic carboxylic acids, amines, imines, nitrogen-substituted derivatives, and aldehydes-on multilamellar liposomes with varying charges were monitored in biological systems. The stabilization-lysis action of amphipathic compounds on liposomes was influenced by either the electrostatic repulsion or the attraction force between these compounds and liposomes.

Journal of Dental Research, Vol. 62, No. 1, 65-68 (1983)
DOI: 10.1177/00220345830620011501
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