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Journal of Dental Research
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Effect of Chinese and Western Antimicrobial Agents on Selected Oral Bacteria

T.-F. Tsao

UCLA School of Dentistry, Section of Periodontics, Los Angeles, California 90024

M.G. Newman

UCLA School of Dentistry, Section of Periodontics, Los Angeles, California 90024

Y.-Y. Kwok

Wadsworth Veterans Administration Hospital, Los Angeles, California 90073

A.K. Horikoshi

UCLA School of Dentistry, Section of Periodontics, Los Angeles, California 90024

The susceptibility of selected oral bacteria, including suspected periodontopathogens, to a commonly employed Chinese herbal medicine Huang-chin (HC, Scutellaria baicalensis) was tested in vitro. The minimum inhibitory concentration (MIC) and minimum bactericidal concentrations (MBC) were determined. HC was also compared with tetracycline, alexidine, and stannous fluoride. HCdecoction, ata concentration of 2%, was bacteriostatic in eight of 11 bacteria tested, but a concentration of 3.13% or greater was required for bactericidal effect. Among the tested bacteria, Bacteroides melaninogenicus ss intermedius was the most sensitive (MIC = 1.57%, MBC = 2%); Actinomyces viscosus was the least sensitive (MIC = 6.25%, MBC 12.5%). Tetracycline, alexidine, and SnF2 were bactericidal in vitro in all bacteria tested at concentrations lower than those used clinically.

Journal of Dental Research, Vol. 61, No. 9, 1103-1106 (1982)
DOI: 10.1177/00220345820610091501
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