This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Tenovuo, J. Articles by Thomas, E.L. Search for Related Content PubMed PubMed Citation Articles by Tenovuo, J. Articles by Thomas, E.L. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Social Bookmarking                         What's this?

Peroxidase Antimicrobial System of Human Saliva: Hypothiocyanite Levels in Resting and Stimulated Saliva

Division of Molecular Biology, University of Alabama in Birmingham, University Station, Birmingham, Alabama 35294

K.M. Pruitt

Division of Molecular Biology, University of Alabama in Birmingham, University Station, Birmingham, Alabama 35294

E.L. Thomas

Department of Biochemistry, St. Jude Children's Research Hospital and The University of Tennessee Center for Health Sciences, Memphis, Tennessee 38101

The antimicrobial oxidizing agent hypothiocyanite ion (OSCN-) was measured in resting (drooling) and stimulated (expectorated) whole saliva. Stimulation of the saliva flow rate resulted in a rapid decrease in OSCN- concentration, whereas the thiocyanate ion (SCN—) concentration and peroxidase activity were increased. The decrease in OSCN — levels was greater than could be accounted for by dilution of the whole saliva volume. Assuming that the antimicrobial activity of the salivary peroxidase system is proportional to OSCN- concentration, this system may be more effective in resting saliva than in stimulated saliva.

Journal of Dental Research, Vol. 61, No. 8, 982-985 (1982)
DOI: 10.1177/00220345820610081301


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				C. Gerson, J. Sabater, M. Scuri, A. Torbati, R. Coffey, J. W. Abraham, I. Lauredo, R. Forteza, A. Wanner, M. Salathe, et al. The Lactoperoxidase System Functions in Bacterial Clearance of Airways Am. J. Respir. Cell Mol. Biol., June 1, 2000; 22(6): 665 - 671. [Abstract] [Full Text]

				M. Lenander-Lumikari, B. Mansson-Rahemtulla, and F. Rahemtulla Lysozyme Enhances the Inhibitory Effects of the Peroxidase System on Glucose Metabolism of Streptococcus mutans Journal of Dental Research, March 1, 1992; 71(3): 484 - 490. [Abstract] [PDF]

				J. Tenovuo, E. Grahn, O.-P. Lehtonen, T. Hyyppa, L. Karhuvaara, and P. Vilja Antimicrobial Factors in Saliva: Ontogeny and Relation to Oral Health Journal of Dental Research, February 1, 1987; 66(2): 475 - 479. [Abstract] [PDF]

				J. Tenovuo, O.-P. Lehtonen, J. Vkari, H. Larjava, P. Vilja, and P. Tuohimaa Immunoglobulins and Innate Antimicrobial Factors in Whole Saliva of Patients with Insulin-dependent Diabetes Mellitus Journal of Dental Research, January 1, 1986; 65(1): 62 - 66. [Abstract] [PDF]

				I.D. Mandel, J. Behrman, R. Levy, and D. Weinstein The Salivary Lactoperoxidase System in Caries-resistant and -susceptible Adults Journal of Dental Research, August 1, 1983; 62(8): 922 - 925. [Abstract] [PDF]