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Journal of Dental Research
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Biological Assessments of Experimental Cavity Cleansers: Correlation Between in vitro and in vivo Studies

LA Mjor

NIOM, Scandinavian Institute of Dental Materials, Oslo, Norway

A. Hensten-Pettersen

NIOM, Scandinavian Institute of Dental Materials, Oslo, Norway

R.L. Bowen

American Dental Association Health Foundation, Research Unit at National Bureau of Standards, Washington, DC 20234

Adhesive bonding of resins to dentin surfaces requires the removal of the layer of debris caused by the cutting. Certain isotonic acidic solutions can do this rapidly. Five solutions were evaluated using cell cultures and pulp studies in monkeys. At concentrations above 10%, each solution caused the cultured human epithelial cells to respond unfavorably, probably due to the low pH of the culture medium. None of these experimental cleanser solutions caused significant pulpal irritation.

Journal of Dental Research, Vol. 61, No. 8, 967-972 (1982)
DOI: 10.1177/00220345820610081001
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W.R. Hume
A New Technique for Screening Chemical Toxicity to the Pulp from Dental Restorative Materials and Procedures
Journal of Dental Research, November 1, 1985; 64(11): 1322 - 1325.
[Abstract] [PDF]