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The Effect of 5,5'-diphenylhydantoin on the Metabolism of 17β-estradiol by Rat Oral Mucosa

Department of Dentistry and Medicine, New York Medical College, Valhalla, New York 10595

P.R. Munnangi

Department of Dentistry and Medicine, New York Medical College, Valhalla, New York 10595

G.G. Gordon

Department of Dentistry and Medicine, New York Medical College, Valhalla, New York 10595

S.C. Rappaport

Department of Dentistry and Medicine, New York Medical College, Valhalla, New York 10595

A.L. Southren

Department of Dentistry and Medicine, New York Medical College, Valhalla, New York 10595

Systemic pretreatment of rats with 5,5'-diphenylhydantoin (DPH) or its addition into an in vitro assay increases microsomal hydroxylation of 17β-estradiol. This increase depends on the concentration of DPH in the microsomal cell compartment.

Journal of Dental Research, Vol. 61, No. 8, 1010-1013 (1982)
DOI: 10.1177/00220345820610080301


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				J. Vittek, G.G. Gordon, P.R. Munnangi, S.C. Rappaport, and A.L. Southren Biosynthesis of 17{beta}-estradiol and Its Binding to Specific Receptors in Human Gingiva Journal of Dental Research, March 1, 1983; 62(3): 341 - 343. [Abstract] [PDF]