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Journal of Dental Research
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*PHENYTOIN SODIUM
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Ultrastructural Quantitation of Connective Tissue Changes in Phenytoin-induced Gingival Overgrowth in the Ferret

B.K. Hall

Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, Iowa 52242

C.A. Squier

Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, Iowa 52242

Ultrastructural quantitation has been used to determine both the effect of phenytoin (PHT) on gingival connective tissue components and the cellular basis for these changes. The results suggest that the amount of ground substance increases, and this may be due to decreased degradation within fibroblasts.

Journal of Dental Research, Vol. 61, No. 7, 942-952 (1982)
DOI: 10.1177/00220345820610071101
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