Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Rao, G.S.
Right arrow Articles by Adatia, M.R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rao, G.S.
Right arrow Articles by Adatia, M.R.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*AMINOPYRINE
*N-NITROSODIMETHYLAMINE
*OXYTETRACYCLINE
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Drug-Nitrite Interactions in Human Saliva: Effects of Food Constituents on Carcinogenic N-Nitrosamine Formation

G.S. Rao

Division of Biochemistry and Laboratory of Pharmacology, Research Institute, American Dental Association Health Foundation, Chicago, Illinois 60611

J.C. Osborn

Division of Biochemistry and Laboratory of Pharmacology, Research Institute, American Dental Association Health Foundation, Chicago, Illinois 60611

M.R. Adatia

Division of Biochemistry and Laboratory of Pharmacology, Research Institute, American Dental Association Health Foundation, Chicago, Illinois 60611

A simple and rapid high-pressure liquid chromatographic assay for monitoring N-nitrosodimethylarnine (NDMA) in human saliva was developed. The method was used to study in vitro the effects of common food constituents on NDMA formation in saliva from the interaction of salivary nitrite with aminopyrine and oxytetracycline. Natural phenolic compounds, caffeic acid, and tannic acid, and synthetic additives, erythorbic acid, sorbic acid, propyl gallate, and butylated hydroxytoluene - all inhibited NDMA formation (20-80%). With ascorbic acid, up to 90% inhibition of NDMA synthesis in saliva was observed. In contrast, chlorogenic acid (a phenolic component of coffee) acted as a catalyst (up to 48% increase) of the nitrosamine formation under identical experimental conditions.

Journal of Dental Research, Vol. 61, No. 6, 768-771 (1982)
DOI: 10.1177/00220345820610062301
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
N. G Hord, Y. Tang, and N. S Bryan
Food sources of nitrates and nitrites: the physiologic context for potential health benefits
Am. J. Clinical Nutrition, July 1, 2009; 90(1): 1 - 10.
[Abstract] [Full Text] [PDF]

Home page
 International Journal of ToxicologyHome page
Final Report on the Amended Safety Assessment of Propyl Gallate
International Journal of Toxicology, May 1, 2007; 26(3_suppl): 89 - 118.
[Abstract] [Full Text] [PDF]

Home page
 International Journal of ToxicologyHome page
4: Final Report on the Safety Assessment of Sorbic Acid and Potassium Sorbate
International Journal of Toxicology, November 1, 1988; 7(6): 837 - 880.
[Abstract] [PDF]

Home page
 International Journal of ToxicologyHome page
2 Final Report on the Safety Assessment of Propyl Gallate
International Journal of Toxicology, May 1, 1985; 4(3): 23 - 64.
[Abstract] [PDF]