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Journal of Dental Research
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Formation of 12L-Hydroxyeicosatetraenoic Acid (12-HETE) by Gingival Tissue

B. Sidhagen

Department of Pharmocology, Karolinska Institutet, S-104 01 Stockholm, Sweden

M. Hamberg

Department of Chemistry, Karolinska Institutet, S-104 01 Stockholm, Sweden

B.B. Fredholm

Department of Pharmocology, Karolinska Institutet, S-104 01 Stockholm, Sweden

Extracts of inflamed human gingival tissue converted exogenous [14C] -arachidonic acid mainly to a non-prostaglandin metabolite. This metabolite was identified as 12-hydroxyeicosatetraenoic acid (12-HETE) by gas-liquid chromatography-mass-spectometry. Endogenous arachidonic acid was also converted to 12-HETE. Significant formation of PGF2{alpha} , PGD2, PGI2, Thromboxane B, or 12-HHT could not be detected, but, in occasional experiments, significant conversion of arachidonic acid to PGE2 was found.

Journal of Dental Research, Vol. 61, No. 6, 761-763 (1982)
DOI: 10.1177/00220345820610062101
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