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Pharmacokinetics of Fluoride from APF Gel and Fluoride Tablets in Children

Department of Pediatric Dentistry, School of Dentistry, Medical College of Virginia, Richmond, Virginia 23298and

G.M. Whitford

Department of Oral Biology-Physiology, School of Dentistry, Medical College of Georgia, Augusta, Georgia 30912

During separate visits, four child volunteers received routine APF gel topical fluoride applications and ingested known amounts of fluoride (3.0 mg) in the form of tablets. Plasma and urine fluoride concentrations, as well as urine excretion rates, were measured before and for five h after these procedures. Significant increases in plasma and urinary fluoride concentrations were observed following both procedures.

Journal of Dental Research, Vol. 61, No. 3, 469-472 (1982)
DOI: 10.1177/00220345820610030501


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