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Properties of Cysteine-containing Phosphoproteins from Human Submandibular-sublingual Saliva

Department of Oral Biology, School of Dentistry, State University of New York at Buffalo, Buffalo, New York 14226

L.A. Tabak

Department of Oral Biology, School of Dentistry, State University of New York at Buffalo, Buffalo, New York 14226

M.J. Levine

Department of Oral Biology, School of Dentistry, State University of New York at Buffalo, Buffalo, New York 14226

I.D. Mandel

School of Dental and Oral Surgery, Columbia University, New York City, New York 10032

D.I. Hay

Forsyth Dental Center, 140 The Fenway, Boston, Massachusetts 02115

Cysteine-containing phosphoproteins (CCP) similar to those found in human submandibular-sublingual saliva have also been detected in parotid saliva and tears suggesting a serous origin. No appreciable difference was found in salivary CCP concentrations between caries-susceptible and caries-resistant individuals. CCPadsorbed to hydroxyapatite, and this binding was due in part to phosphate residues. In addition, these molecules inhibited the transformation of dicalcium phosphate dihydrate, albeit to a lesser extent than statherin.

Journal of Dental Research, Vol. 61, No. 2, 397-399 (1982)
DOI: 10.1177/00220345820610020601


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