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Journal of Dental Research
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*PILOCARPINE
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Relationship Between Frequency of Pilocarpine Administration and Salivary IgA Level

D.J. Smith

Department of Immunology, Forsyth Dental Center, 140 The Fenway, Boston, Massachusetts 02115

M.A. Taubman

Department of Immunology, Forsyth Dental Center, 140 The Fenway, Boston, Massachusetts 02115

J.L. Ebersole

Department of Immunology, Forsyth Dental Center, 140 The Fenway, Boston, Massachusetts 02115

W. King

Department of Immunology, Forsyth Dental Center, 140 The Fenway, Boston, Massachusetts 02115

The effect of repetitive administration of pilocarpine nitrate on the salivary volume and salivary IgA concentration was studied in the NIH white hamster. One and one-half to three-fold increases in salivary volume, coupled with decreases of 1/3 to 2/3 in IgA concentration, occurred as the frequency of administration of pilocarpine increased.

Journal of Dental Research, Vol. 61, No. 12, 1451-1453 (1982)
DOI: 10.1177/00220345820610121601
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