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Journal of Dental Research
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Effect of Topically-applied Solutions of Iodine, Sodium Fluoride, or Chlorhexidine on Oral Bacteria and Caries in Rats

Page W. Caufield

University of Alabama in Birmingham, School of Dentistry and Institute of Dental Research, Birmingham, Alabama 35294

Juan M. Navia

University of Alabama in Birmingham, School of Dentistry and Institute of Dental Research, Birmingham, Alabama 35294

Angela M. Rogers

University of Alabama in Birmingham, School of Dentistry and Institute of Dental Research, Birmingham, Alabama 35294

Celestino Alvarez

University of Alabama in Birmingham, School of Dentistry and Institute of Dental Research, Birmingham, Alabama 35294

Antibacterial levels of iodine, chlorhexidine, or sodium fluoride were topically applied to the molar teeth of rats. The effect of these agents on buccal and sulcal caries, as well as on certain oral bacterial populations was assayed. All three agents exerted a significant cariostatic effect which was site specific. Buccal caries incidence and reductions appeared correlated to S. mutans counts, while sulcal caries was better correlated to total cultivable counts. These studies suggested that the simultaneous application of iodine and NaF might exert an additive cariostatic effect.

Journal of Dental Research, Vol. 60, No. 5, 927-932 (1981)
DOI: 10.1177/00220345810600051301
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