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Journal of Dental Research
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Binding of Eugenol and O-ethoxybenzoic Acid to Bovine Serum Albumin

Sechiro Fujisawa

School of Dentistry, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113,

Echi Masuhara

Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, 2-3-10 Surugadai, Kanda, Chiyoda-ku, Tokyo 101, Japan,

The binding constants (log K) of eugenol, o-ethoxybenzoic acid, and their analogues, plus other organic compounds widely used in dentistry with bovine serum albumin, were examined with respect to the partition coefficients of these compounds in octanol-water (log P). Linear relationships between log K and log P values were obtained with high relative coefficients. Eugenol and o-ethoxybenzoic acid showed a relatively large log K value.

Journal of Dental Research, Vol. 60, No. 4, 860-864 (1981)
DOI: 10.1177/00220345810600041801
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