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Thiocyanate as a Cofactor in Myeloperoxidase Activity Against Streptococcus mutans

Henk W. Kersten

Department of Cariology and Endodontology, University of Amsterdam, Louwesweg 1, 1066 EA Amsterdam, The Netherlands

Wilfred R. Moorer

Department of Cariology and Endodontology, University of Amsterdam, Louwesweg 1, 1066 EA Amsterdam, The Netherlands

Ron Wever

Department of Biochemistry, University of Amsterdam, B.C.P. Jansen Institute, Plantage Muidergracht 12, 1018 TV Amsterdam, The Netherlands

Inhibition of glycolysis of some oral bacteria was established in vitro by an antibacterial system, consisting of myeloperoxidase, H202, and a cofactor. When thiocyanate was used in physiological concentration as a cofactor, the system acted (at low pH) bactericidally on Streptococcus mutans, as indicated by the determination of viable counts. However, at neutral pH, the glycolysis of Streptococcus mutans was inhibited, while its viability remained unaffected. The possible role of such a pH-dependent antibacterial system in the oral cavity is discussed.

Journal of Dental Research, Vol. 60, No. 4, 831-837 (1981)
DOI: 10.1177/00220345810600041201
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