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Journal of Dental Research
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Clinical Science

In vivo Enamel Fluoride Uptake from and Caries Inhibition by Topical Fluoride Agents

M. Gibbs

Institute of Dental Research, University of Alabama School of Dentistry

D.H. Retief

E.L. Bradley

Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35294

R.E. Taylor

Institute of Dental Research, University of Alabama School of Dentistry

A.R. Walker

Institute of Dental Research, University of Alabama School of Dentistry

Acidulated phosphate fluoride (APF), Duraphat or Fluor Protector, was applied to the molar teeth of rats fed a cariogenic diet. The first maxillary molar teeth were subjected to a microbiopsy procedure for fluoride analysis and the mandibular molars scored for caries. All three topical fluoride agents produced a significant increase in the fluoride content of the outermost 5.0 µm of enamel. Only APF produced a significant reduction in caries incidence at all sites.

Journal of Dental Research, Vol. 60, No. 4, 770-775 (1981)
DOI: 10.1177/00220345810600040101
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D.G.A. Nelson, W.L. Jongebloed, and J. Arends
Morphology of Enamel Surfaces Treated with Topical Fluoride Agents: SEM Considerations
Journal of Dental Research, December 1, 1983; 62(12): 1201 - 1208.
[Abstract] [PDF]