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Journal of Dental Research
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Rapid Quantitative Determination of the Effect of Antiplaque Agents and Antisera on the Growth, Acid Production, and Adherence of Streptococcus mutans

J.E. Ciardi

National Caries Program, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20205

A.B. Rosenthal

National Caries Program, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20205

W.H. Bowen

National Caries Program, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20205

A rapid quantitative in vitro assay measured the effects of antiplaque agents and antiserum on growth and sucrose-mediated adherence of radiolabeled S. mutans 6715. Acid production was measured by change in pH. In this assay the primary effect of chlorhexidine and fluoride was bacteriostasis and inhibition of acid production, respectively; the primary effect of dextran, dextranase, and specific antiserum was inhibition of sucrose-mediated adherence.

Journal of Dental Research, Vol. 60, No. 3, 756-762 (1981)
DOI: 10.1177/00220345810600031701
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