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Journal of Dental Research
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Alteration of Lidocaine- or Procaine-induced Convulsions by Manipulation of Brain Amines

Alfred E. Ciarlone

Departments of Oral Biology and Pharmacology, Schools of Dentistry and Medicine, Medical College of Georgia, Augusta, Georgia 30912

Lidocaine and procaine seizure thresholds were studied. The i.p. median convulsant dose (CD50) of lidocaine and procaine with saline pre-treatment was 95 and 240 mg/kg, respectively. Dopamine depletion by pre-treatment with d1-{alpha}-methyl-p-tyrosine plus dihydroxyphenylserine resulted in a significant drop of CD50 to 69 and 175 mg/kg for lidocaine and procaine, respectively. Serotonin depletion by pre-treatment with p-chlorophenylalanine resulted in a significant drop of CD50 to 68 mg/kg for lidocaine, but no significant change for procaine.

Journal of Dental Research, Vol. 60, No. 2, 182-186 (1981)
DOI: 10.1177/00220345810600021701
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