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Hypothiocyanite Ion: Detection of the Antimicrobial Agent in Human Saliva

Department of Biochemistry, St. Jude Children's Research Hospital, and The University of Tennessee Center for the Health Sciences, Memphis, Tennessee 38101

Kate Pera Bates

Department of Biochemistry, St. Jude Children's Research Hospital, and The University of Tennessee Center for the Health Sciences, Memphis, Tennessee 38101

M. Margaret Jefferson

Department of Biochemistry, St. Jude Children's Research Hospital, and The University of Tennessee Center for the Health Sciences, Memphis, Tennessee 38101

The median concentration of hypothiocyanite (OSCN-) in freshly collected whole saliva was 10 µM. The OSCN- concentration increased to a median value of 36 µM during incubation for one h at 37° in vitro. This increase was partially inhibited by adding certain sugars (especially sucrose). The results suggest that OSCN- is a naturally occurring component of human saliva. Also, dietary carbohydrate may inhibit OSCN- accumulation and antimicrobial action in saliva.

Journal of Dental Research, Vol. 59, No. 9, 1466-1472 (1980)
DOI: 10.1177/00220345800590090201


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