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Journal of Dental Research
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Calcium and cGMP in Isolated Rat Parotid Acinar Cells

J.A. Mangos

Departments of Pediatrics and Basic Dental Sciences, University of Florida, Colleges of Medicine and Dentistry, Gainesville, Florida 32610

R.L. Boyd

Departments of Pediatrics and Basic Dental Sciences, University of Florida, Colleges of Medicine and Dentistry, Gainesville, Florida 32610

D. Bouchlas

Departments of Pediatrics and Basic Dental Sciences, University of Florida, Colleges of Medicine and Dentistry, Gainesville, Florida 32610

W. Farnham

Departments of Pediatrics and Basic Dental Sciences, University of Florida, Colleges of Medicine and Dentistry, Gainesville, Florida 32610

The role of calcium ions in the activation of guanylate cyclase and in the propagation of the effects of cGMP during activation of the muscarinic cholinergic receptors was studied in isolated rat parotid acinar cells. It was demonstrated that the requirement for extracellular calcium is complete in the transduction of information from the muscarinic receptor to the guanylate cyclase, and partial in the steps beyond the synthesis of cGMP.

Journal of Dental Research, Vol. 59, No. 8, 1442-1446 (1980)
DOI: 10.1177/00220345800590081401
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