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Journal of Dental Research
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Subcutaneously Implanted Alginate as a Continuous-release Source of Fluoride

Gary M. Whitford

Department of Oral Biology-Physiology, School of Dentistry, Medical College of Georgia, Augusta, Georgia 30901

Jan Ekstrand

Department of Cariology, Karolinska Institute, School of Dentistry, Huddinge, Sweden

Richard S. Callan

Department of Oral Biology-Physiology, School of Dentistry, Medical College of Georgia, Augusta, Georgia 30901

David E. Pearson

Department of Oral Biology-Physiology, School of Dentistry, Medical College of Georgia, Augusta, Georgia 30901

The fluoride concentrations of seven brands of alginate ranged from 8600 to 30,500 ppm. In acute and chronic in vivo studies, fluoride was continuously released from subcutaneously implanted alginate cylinders for up to three weeks. This technique is a simple and economical method for elevating soft and hard tissue fluoride levels.

Journal of Dental Research, Vol. 59, No. 2, 186-191 (1980)
DOI: 10.1177/00220345800590021901
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E. Joseph Lecompte and G. M. Whitford
The Biologic Availability of Fluoride from Alginate Impressions and APF Gel Applications in Children
Journal of Dental Research, April 1, 1981; 60(4): 776 - 780.
[Abstract] [PDF]