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Journal of Dental Research
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Acyclovir Therapy for the Orofacial and Ganglionic HSV Infection in Hairless Mice

No-Hee Park

Department of Ophthalmology, Harvard Medical School, Department of Cornea Research, Eye Research Institute of Retina Foundation, Harvard School of Dental Medicine, Boston, Massachusetts 02114

Deborah Pavan-Langston

Department of Ophthalmology, Harvard Medical School, Department of Cornea Research, Eye Research Institute of Retina Foundation, Harvard School of Dental Medicine, Boston, Massachusetts 02114

Michael E. Hettinger

Department of Ophthalmology, Harvard Medical School, Department of Cornea Research, Eye Research Institute of Retina Foundation, Harvard School of Dental Medicine, Boston, Massachusetts 02114

Acyclovir (ACV) therapy, topical or systemic, showed a significantly high therapeutic efficacy for facial Herpes Simplex Virus (HSV) infection in hairless mice. When topical ACV treatment was initiated very early, i.e., three h post-inoculation, the number of mice with latent HSV infection in their trigeminal ganglia was significantly reduced. These results indicate that ACV clearly merits further investigation as an antiviral agent for therapy of orofacial HSV infections.

Journal of Dental Research, Vol. 59, No. 12, 2080-2086 (1980)
DOI: 10.1177/00220345800590121101
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