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Prostaglandin as a Mediator of Bone Resorption Induced by Experimental Tooth Movement in Rats

Department of Orthodontics, School of Dentistry, Tokyo Medical and Dental University, 1-545, Yushima, Bunkyo-ku, Tokyo 113, Japan

Fujio Miura

Department of Orthodontics, School of Dentistry, Tokyo Medical and Dental University, 1-545, Yushima, Bunkyo-ku, Tokyo 113, Japan

Tatsuo Suda

Department of Biochemistry, Showa University Dental School, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo 142, Japan

Administration of indomethacin inhibited the appearance of osteoclasts and bone resorption induced by experimental tooth movement in rats. Effects were limited to groups injected within 12 h after treatment.

Prostaglandin E₁ or E₂ solutions injected in gingiva lying near the upper first molar caused the appearance of osteoclasts and bone resorption.

Journal of Dental Research, Vol. 59, No. 10, 1635-1642 (1980)
DOI: 10.1177/00220345800590101301


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