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Cariogenicity of Mutants of Streptococcus mutans

Michael W.H. Mao

College of Dentistry, The Ohio State University, Columbus, Ohio 43210

Sam Rosen

College of Dentistry, The Ohio State University, Columbus, Ohio 43210

In this study, we induced a number of mutants of S. mutans differing in their abilities to synthesize glucan and produce acid. When tested for cariogenicity in gnotobiotic rats, "high pH" mutants caused less caries, but could not supplant a cariogenic parent strain.

Journal of Dental Research, Vol. 59, No. 10, 1620-1626 (1980)
DOI: 10.1177/00220345800590101101
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