|
Sign In to gain access to subscriptions and/or personal tools.
|
Enamel Protein Chemistry - Past, Present and Future
J.E. Eastoe
Department of Dental Science, Royal College of Surgeons of England, Lincoln's Inn Fields, London, WC2A 3PN, England
Past progress in the chemistry of enamel proteins is reviewed and the current state of knowledge assessed. The matrix of young enamel is a complex system in which some 20 distinct components with molecular weights in the region of 3,000 to 16,000 are in dynamic equilibrium with much larger aggregates. During maturation, most of these components are selectively lost, more or less completely, from the enamel. 'Amelogenin' components rich in proline and histidine are removed first and 'tuft protein', characterized by high serine and glycine, is often partially retained in mature enamel. Some components have been isolated in a state approaching purity and a measure of agreement has been reached between laboratories concerning their characteristics. Partial amino acid sequences are known for two components, which contain phosphoserine. Though the mechanisms of mineralization and protein removal are not known, various possibilities are discussed. The essential unsolved problem is the nature of the overall protein system.
Journal of Dental Research, Vol. 58, No. 2 suppl,
753-764 (1979)
DOI: 10.1177/00220345790580022701
 CiteULike  Complore  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter What's this?
This article has been cited by other articles:
|
|
|
|
 
J. J. Caterina, Z. Skobe, J. Shi, Y. Ding, J. P. Simmer, H. Birkedal-Hansen, and J. D. Bartlett
Enamelysin (Matrix Metalloproteinase 20)-deficient Mice Display an Amelogenesis Imperfecta Phenotype
J. Biol. Chem.,
December 13, 2002;
277(51):
49598 - 49604.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.D. Bartlett and J.P. Simmer
Proteinases in Developing Dental Enamel
Critical Reviews in Oral Biology & Medicine,
July 1, 1999;
10(4):
425 - 441.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Tan, W. Leung, J. Moradian-Oldak, M. Zeichner-David, and A.G. Fincham
Quantitative Analysis of Amelogenin Solubility
Journal of Dental Research,
June 1, 1998;
77(6):
1388 - 1396.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C.E. Smith
Cellular and Chemical Events During Enamel Maturation
Critical Reviews in Oral Biology & Medicine,
January 1, 1998;
9(2):
128 - 161.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Deutsch, E. Chityat, M. Hekmati, A. Palmon, Y. Farkash, and L. Dafni
High Expression of Human Amelogenin in E. Coli
Advances in Dental Research,
November 1, 1996;
10(2):
187 - 194.
[Abstract]
[PDF]
|
|
|
|
|
|
|
T Diekwisch, S David, P Bringas, V Santos, and H. Slavkin
Antisense inhibition of AMEL translation demonstrates supramolecular controls for enamel HAP crystal growth during embryonic mouse molar development
Development,
January 2, 1993;
117(2):
471 - 482.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. Deutsch, A. Palmon, J. Catalano-Sherman, and R. Laskov
Production of Monoclonal Antibodies Against Enamelin and Against Amelogenin Proteins of Developing Enamel Matrix
Advances in Dental Research,
December 1, 1987;
1(2):
282 - 288.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M.F. Young, H.S. Shimokawa, M.E. Sobel, and J.D. Termine
A Characterization of Amelogenin Messenger RNA in the Bovine Tooth Germ
Advances in Dental Research,
December 1, 1987;
1(2):
289 - 292.
[Abstract]
[PDF]
|
|
|
|
|
|
|
Y. Doi, E.D. Eanes, H. Shimokawa, and J.D. Termine
Inhibition of Seeded Growth of Enamel Apatite Crystals by Amelogenin and Enamelin Proteins in vitro
Journal of Dental Research,
February 1, 1984;
63(2):
98 - 105.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A.G. Fincham, A.B. Belcourt, and J.D. Termine
Molecular Composition of the Protein Matrix of Developing Human Dental Enamel
Journal of Dental Research,
January 1, 1983;
62(1):
11 - 15.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A.B. Belcourt, A.G. Fincham, and J.D. Termine
Acid-soluble Bovine Fetal Enamelins
Journal of Dental Research,
August 1, 1982;
61(8):
1031 - 1032.
[Abstract]
[PDF]
|
|
|
|
|
