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Journal of Dental Research
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*PHENYTOIN SODIUM
*TESTOSTERONE
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Cellular Regulation of the Metabolism of Androgens in Rat Oral Mucosa. III. Activation of {Delta}4-3-ketosteroid-5{alpha}-A Ring Reductase Enzyme System by 5,5-Diphenylhydantoin

Jozef Vittek

Department of Medicine, New York Medical College, New York 10029, U.S.A., Department of Dentistry, New York Medical College, New York 10029, U.S.A.

Gary G. Gordon

Department of Medicine, New York Medical College, New York 10029, U.S.A., Department of Dentistry, New York Medical College, New York 10029, U.S.A.

Sydney C. Rappaport

Department of Medicine, New York Medical College, New York 10029, U.S.A., Department of Dentistry, New York Medical College, New York 10029, U.S.A.

A. Louis Southren

Department of Medicine, New York Medical College, New York 10029, U.S.A., Department of Dentistry, New York Medical College, New York 10029, U.S.A.

Systemic pretreatment of rats with diphenylhydantoin (DPH) or its addition into an in vitro assay increases 5{alpha}-reduction of testosterone by the oral mucosa. Enzyme kinetic studies showed that DPH binds to the enzyme and probably activates it by an allosteric mechanism.

Journal of Dental Research, Vol. 58, No. 2, 642-645 (1979)
DOI: 10.1177/00220345790580021901
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J. Vittek, P.R. Munnangi, G.G. Gordon, S.C. Rappaport, and A.L. Southren
The Effect of 5,5'-diphenylhydantoin on the Metabolism of 17{beta}-estradiol by Rat Oral Mucosa
Journal of Dental Research, August 1, 1982; 61(8): 1010 - 1013.
[Abstract] [PDF]