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Journal of Dental Research
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Collagenolytic Activity of Crevicular Fluid and of Adjacent Gingival Tissue

Lorne M. Golub

Department of Oral Biology and Pathology, School of Dental Medicine, State University of New York at Stony Brook, Stony Brook, New York 11794

Robert Kaplan

Department of Dentistry, Long Island Jewish-Hillside Medical Center, New Hyde Park, New York 11040

James E. Mulvihill

Department of Dentistry, Long Island Jewish-Hillside Medical Center, New Hyde Park, New York 11040

N.S. Ramamurthy

Department of Oral Biology and Pathology, School of Dental Medicine, State University of New York at Stony Brook, Stony Brook, New York 11794

The fluid in and gingival tissue lining periodontal pockets were collected from male patients undergoing periodontal therapy. The collagenolytic activity of the crevicular fluid, and the ability of the gingiva in culture to degrade (a) an exogenous collagen substrate, and (b) endogenous collagen newly synthesized and labeled with H3-hydroxyproline, were related to the severity of gingival inflammation. Although inflammation appeared to have only a slight effect on gingival collagenolytic activity and on the turnover of collagen newly synthesized in culture, a marked effect was observed on the collagenase activity in the crevicular fluid. This study suggests that the collagen destructive activity of the periodontal lesion can be assessed by monitoring crevicular fluid collagenolytic activity.

Journal of Dental Research, Vol. 58, No. 11, 2132-2136 (1979)
DOI: 10.1177/00220345790580111601
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This article has been cited by other articles:


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D.A. Eisenhauer, R. Hutchinson, T. Javed, and J.K. McDonald
Identification of a Cathepsin B-like Protease in the Crevicular Fluid of Gingivitis Patients
Journal of Dental Research, August 1, 1983; 62(8): 917 - 921.
[Abstract] [PDF]

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K. Jima, K. Ando, M. Kishi, T. Nakashizuka, and T. Hayakawa
Collagenase Activity in Human Saliva
Journal of Dental Research, June 1, 1983; 62(6): 709 - 712.
[Abstract] [PDF]