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Journal of Dental Research
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Radiochemical Determination of the Metabolic Activity of Collagen in Mature Dentin

J.M.P.M. Borggreven

Laboratory of Oral Biochemistry, School of Dentistry, University of Nijmegen, Nijmegen, The Netherlands

P.M.M. Hoppenbrouwers

Laboratory of Oral Biochemistry, School of Dentistry, University of Nijmegen, Nijmegen, The Netherlands

R. Gorissen

Laboratory of Oral Biochemistry, School of Dentistry, University of Nijmegen, Nijmegen, The Netherlands

Tritiated proline was administered to domestic cats during the development of their permanent premolars. The metabolic activity of collagen in the mature premolar dentin was determined by quantitating the amount of tritiated hydroxyproline in the dentin as a function of time. It has been demonstrated that the metabolic activity of the dentinal collagen was extremely low and remained within the experimental error for a period of 45 weeks.

Journal of Dental Research, Vol. 58, No. 11, 2120-2124 (1979)
DOI: 10.1177/00220345790580111401
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P.M.M. Hoppenbrouwers, J.M.P.M. Borggreven, G.S.T. The, and J.C. Maltha
Clinical Science: The Effect of Cavity Preparation on the Metabolism of Protein in Dentin
Journal of Dental Research, September 1, 1982; 61(9): 1035 - 1038.
[Abstract] [PDF]

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P.M.M. Hoppenbrouwers, J.M.P.M. Borggreven, and J.C. Maltha
Autoradiographic Determination of the Metabolic Activity of Protein in Mature Dentin
Journal of Dental Research, January 1, 1982; 61(1): 49 - 51.
[Abstract] [PDF]