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Journal of Dental Research
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The Effect of Epinephrine on Pulpal Microcirculation

Solange Simard-Savoie

Department of Stomatology, Faculty of Dental Medicine, Université de Montréal, Montreal, Quebec

Helene Lemay

Department of Stomatology, Faculty of Dental Medicine, Université de Montréal, Montreal, Quebec

Larbi Taleb

Department of Stomatology, Faculty of Dental Medicine, Université de Montréal, Montreal, Quebec

The effect of epinephrine (Epi) on the microcirculation of the pulp and its neuropharmacological mechanism has been established, as well as the existence of alpha adrenergic receptors in the blood vessels of the pulp. In addition, our results showed that local injections of Epi at doses greater than 10-8 M produced an extreme drop in intrapulpal pressure (IPP). This effect was not obtained when Epi was injected intravenously.

Journal of Dental Research, Vol. 58, No. 11, 2074-2079 (1979)
DOI: 10.1177/00220345790580110601
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T. Jima, J.Q. Zhang, T. Goto, T. Kondo, and T. Tanaka
A Scanning Electron Microscopic Study of the Contraction of Vascular Wall Cells in Dog Dental Pulp
Journal of Dental Research, November 1, 1991; 70(11): 1456 - 1461.
[Abstract] [PDF]